Prevalence of Manifestations of Afferent Baroreflex Failure Among Long-Term Survivors of Oropharyngeal Cancer.

ABSTRACT:

Background

Afferent baroreflex failure (ABF) is an underrecognized but debilitating complication among head and neck cancer survivors, especially in oropharyngeal cancer (OPC), a malignancy with excellent prognosis. ABF is mainly caused by radiation therapy (RT), with neck surgery and some chemotherapies also contributing. It manifests as blood pressure lability, including severe hypertension or hypotension, syncope, and arrhythmias.

Objectives

To determine the prevalence and predictors of ABF-associated manifestations among OPC survivors treated with modern RT.

Methods

We retrospectively studied OPC patients treated with RT at a tertiary cancer center between 2016-2019. Clinical data were collected from RT initiation to last follow-up or death. ABF-associated manifes

SUBMITTER: Van-Bergen PJ 

PROVIDER: S-EPMC12687976 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature