Effects of collagen tripeptide supplementation on oxidative stress and mitochondrial function in aging.

ABSTRACT:

Background/objectives

Aging is often accompanied by chronic oxidative stress, contributing to the progression of metabolic disorders. A previous study reported that supplementation with collagen tripeptide (CTP) inhibits fatty liver and lipid hypertrophy, but the mechanism is unclear.

Materials/methods

This study examined the effects of 12-week CTP supplementation on oxidative stress, insulin resistance, and adenosine monophosphate-activated protein kinase (AMPK) α activation, key factors in metabolic disorders in aged mice. Thirty-eight male C57BL/6J mice (58 weeks old) were assigned to 4 groups: aging control, 0.03% Gly-Pro-Hyp, 0.9% CTP, and 0.9% granulated collagen tripeptide (gCTP) supplementation. A group of young mice (YC, n = 8) served as the positive control.

Res

SUBMITTER: Kim CE 

PROVIDER: S-EPMC12688003 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature