N-3 highly unsaturated fatty acids combined with pro-biotics or post-biotics synergistically alleviate dyslipidemia in rats exposed to chronic mild stress.

ABSTRACT:

Background/objectives

This research is objective to examine the synergistic hypocholesterolemic effects of n-3 highly unsaturated fatty acids (HUFA) combined with pro- or post-biotics on dyslipidemia caused by chronic mild stress (CMS) through modulating biosynthesis and clearance of cholesterol.

Materials/methods

Rats were assigned into 7 random groups, each containing 8 rats: n-3 HUFA deficient diet without CMS, CMS with n-3 HUFA deficient diet, pro-biotics, post-biotics, n-3 HUFA, n-3 HUFA with pro-biotics, and n-3 HUFA with post-biotics. The induction of CMS occurred over 5 weeks during the 12-week dietary supplementation period.

Results

The n-3 HUFA, pro-biotics, and post-biotics ameliorated dyslipidemia caused by CMS and downregulated cholesterol biosynthesis th

SUBMITTER: Lee J 

PROVIDER: S-EPMC12688008 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature