Imaging protoporphyrin IX photoproduct accumulation as a dosimetry reporter for monitoring photodynamic therapy of oral cancer.

ABSTRACT:

Significance

Photodynamic therapy (PDT) for the treatment of oral cancers and oral potentially malignant lesions can be enhanced by the capability of the photosensitizer to serve as a fluorescence contrast agent for treatment guidance. The development of image-based dosimetry reporters can inform treatment progress in real time to avoid under-treatment, leading to incomplete response and recurrence.

Aim

We investigate the hypothesis that imaging of protoporphyrin IX (PpIX) photoproduct (PP) accumulation may be leveraged as an implicit PDT dosimetry reporter for PDT using 5-aminolevulinic acid (ALA)-induced PpIX photosensitization.

Approach

In initial spectroscopy studies, we investigate dose-dependent changes in absorption and fluorescence spectra of PpIX correspondin

SUBMITTER: Liboy C 

PROVIDER: S-EPMC12688037 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature