Xanthine Oxidase-Dependent Activation of NLPR3 Inflammasome in Epithelial Cells Sustains Inflammation in Inflammatory Bowel Disease.

ABSTRACT:

Importance and objective

Xanthine oxidase (XO) plays a key role in purine metabolism, catalyzing the oxidation of hypoxanthine to xanthine, and xanthine to uric acid (UA) with the production of superoxide anions. The accumulation of UA has been shown to initiate the inflammatory process through NLRP3 inflammasome, and the production of reactive oxygen species (ROS) contributes to inflammation-related tissue damage in different organs. This study aimed to investigate the role of XO in the pathogenesis of Inflammatory Bowel Disease (IBD) and the anti-inflammatory potential of XO inhibition.

Design

XO expression and activity were assessed in the mucosa of moderately-to-severely active ulcerative colitis (UC) and Crohn's disease (CD) patients. The functional role of XO, the acti

SUBMITTER: Di Petrillo A 

PROVIDER: S-EPMC12688067 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature