Early-Life Body Mass Index and Inflammatory Bowel Disease Risk: A Scandinavian Birth Cohort Study.

ABSTRACT:

Introduction

Childhood overweight and obesity are emerging global health issues with potential implications for immune function. We aimed to investigate childhood body mass index (BMI) as a risk factor for later inflammatory bowel disease (IBD).

Methods

ABIS (Sweden) and MoBa (Norway) are population-based cohorts following participants prospectively from birth (1997-2009) until 2023. We retrieved anthropometric data at birth, 1, 3, and 7-8 years to examine the association of age-specific standardized BMI percentiles and categories (underweight, normal [reference), overweight, obesity) with later IBD. We also analyzed IBD risk according to BMI trajectories across ages. IBD diagnosis was identified in national health registries. Cohort-specific hazard ratios (aHRs) were adjust

SUBMITTER: Lerchova T 

PROVIDER: S-EPMC12688070 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature