Chronobiological analysis of sex differences in electrocardiographic parameters in spontaneously breathing Wistar rats under tiletamine-zolazepam anaesthesia.

ABSTRACT:

Introduction

General anaesthesia is essential in surgical interventions because it reduces stress and restricts the animal's movement. However, it can interfere with the circadian clock and, consequently, with several physiological functions, including the cardiovascular system. A combination of tiletamine and zolazepam is rarely used in rat studies; therefore, its effect on cardiovascular function in the context of sex and the light/dark cycle remains unknown.

Aim

This study analysed the effect of sex and the light/dark cycle on electrocardiographic parameters in Wistar rats anaesthetised with tiletamine-zolazepam.

Methods

Experiments were performed on spontaneously breathing Wistar rats of both sexes following a 4-week adaptation to a light/dark (12h/12h) cycle. Aft

SUBMITTER: Novotna V 

PROVIDER: S-EPMC12688129 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature