Random time-shift approximation enables hierarchical Bayesian inference of mechanistic within-host viral dynamics models on large datasets.

ABSTRACT: Mechanistic mathematical models of within-host viral dynamics are tools for understanding how a virus' biology and its interaction with the immune system shape the infectivity of a host. The biology of the process is encoded by the structure and parameters of the model that can be inferred statistically by fitting to viral load data. The main drawback of mechanistic models is that this inference is computationally expensive because the model must be repeatedly solved. This limits the size of the datasets that can be considered or the complexity of the models fitted. In this paper we develop a much cheaper inference method for this class of models by implementing a novel approximation of the model dynamics that uses a combination of random and deterministic processes. This approximation als

SUBMITTER: Morris DJ 

PROVIDER: S-EPMC12688156 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature