Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer.

ABSTRACT: High-grade serous ovarian carcinoma (HGSOC) associates with the worst patient outcome. Understanding the tumor environment in terms of quantifying endogenous retroviruses (ERVs) and LINE-1 expression and their correlations with inflammation genes, checkpoint inhibitors and patient survival is needed. Analysis of 102 treatment-naïve HGSOC and control tissues for ERVs, LINE-1, inflammation and immune checkpoints identified five clusters with diverse patient recurrence-free survivals. One cluster termed Triple-I with the best patient survival showed the highest number of tumor infiltrating lymphocytes along with 22 overexpressed genes, including CXCL9 and AIM2. However, Triple-I associated with the lowest ERV/LINE-1 expression. The tumor cluster with the second-best patient survival had both

SUBMITTER: Glossner L 

PROVIDER: S-EPMC12688164 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature