Functional NK engagers from OmniClic, a common light-chain platform producing fully human-sequence antibodies in a chicken host species.

ABSTRACT: Next-generation antibodies include a growing number of bispecific and multispecific antibodies that are commonly used to redirect the immune system to fight cancer. Herein, we assessed the depth and breadth of epitope coverage as a proxy for functional diversity in human immune repertoires produced by two complementary in vivo platforms utilizing a common light chain, in a chicken (OmniClic^TM) or rat (OmniFlic®) host species. We adopted NKp46 as a model to target antigen due to its use in emerging natural killer (NK) immune engagers that are being explored clinically as potentially safer alternatives to traditional CD3-based T cell engagers. To probe the epitope diversity of our antibody repertoires, we performed a detailed high throughput epitope binning study using surf

SUBMITTER: Zeng B 

PROVIDER: S-EPMC12688219 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature