Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid-TGR5 axis.

ABSTRACT:

Background

Osteoporosis is an age-related disease. The relationship between gut microbiota (GM) homeostasis and bone health is well established, but the mechanism of GM dysbiosis contributes to senile osteoporosis remains elusive. The objective of this study is to investigate the relationship between GM, bile acids (BAs) and their effects on bone mass.

Results

16S rRNA sequencing and untargeted and targeted metabolomics revealed a reduction in microbial diversity, accompanied by the change of BA profile. In particular, the abundance of Parabacteroides goldsteinii and hyodeoxycholic acid (HDCA) in old mice were markedly decreased, compared with young mice. And there was a strong positive correlation between the abundance of P. goldsteinii and HDCA and bone mass.

SUBMITTER: Zheng XQ 

PROVIDER: S-EPMC12688228 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature