A vegan diet signature from a multi-omics study on different European populations is related to favorable metabolic outcomes.

ABSTRACT: Vegan and omnivorous diets differ markedly in composition, but their effects on the gut microbiome, metabolome, and lipidome across populations remain insufficiently characterized. While both diet and country of origin influence these molecular layers, the relative contribution of diet versus country-specific factors has not yet been systematically evaluated within a multi-omics framework.In this cross-sectional, bicentric, observational study, we profiled healthy vegans (n = 100) and omnivores (n = 73) from the Czech Republic and Italy using integrated microbiome, metabolome, and lipidome analyses. Findings were subsequently validated in an independent cohort (n = 142).Significant differences across all omics layers were observed for both country and diet. The predict

SUBMITTER: Ouradova A 

PROVIDER: S-EPMC12688234 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature