Cumulative Life Course Impairment in Moderate-to-Severe Atopic Dermatitis: A Cross-Sectional Study in Singapore.

ABSTRACT:

Introduction

Atopic dermatitis (AD) is a chronic inflammatory skin disease with lifelong consequences for patients' well-being. Quality-of-life tools such as Dermatology Life Quality Index (DLQI) and Patient-Oriented Eczema Measure (POEM) assess disease burden at a specific time point but do not capture long-term life course impairment. The cumulative life course impairment (CLCI) model describes the multidimensional, cumulative effects of a chronic condition over an individual's life course, influencing their trajectory and fulfilment. Two instruments to assess CLCI were recently developed. The CLCI-R assesses retrospective, irreversible cumulative damage since disease onset, while the CLCI-P identifies patients at risk of future life course impairment. Both tools measure the psyc

SUBMITTER: Ho MJ 

PROVIDER: S-EPMC12688327 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature