Sex Differences in Polyvascular Disease　- Implications for Lipid-Lowering Management and Cardiovascular Outcomes.

ABSTRACT:

Background

Sex differences exist in atherosclerotic cardiovascular disease, partly due to the anti-atherosclerotic properties of estrogens in women. While polyvascular disease (PolyVD) exhibits worse outcomes, it is unknown whether women have an impact on cardiovascular outcomes of PolyVD.

Methods and results

We analyzed 678 coronary artery disease patients receiving PCI. PolyVD was defined as the concomitance of ischemic stroke and/or lower extremity arterial disease (LEAD). The occurrence of 3-year major adverse cardiovascular events (MACE; i.e., all-cause death + non-fatal myocardial infarction + ischemic stroke + ischemic-driven non-culprit lesion revascularization + LEAD) was compared between men and women with and without PolyVD, respectively. Women accounted for 17.8%

SUBMITTER: Katasako-Yabumoto A 

PROVIDER: S-EPMC12688431 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature