(Iso)quinoline-Modified Aza-Boron-Dipyrromethenes Near-Infrared-II Fluorescence/Photoacoustic Nanotheranostics for Cervical Tumor Photothermal Therapy.

ABSTRACT: NIR-II small-molecule-based bimodal imaging systems accurately unify diagnosis and therapeutics for precision tumor therapy, which is attributed to their easily modifiable structures, high potential biocompatibility. In particular, the highly efficient photodiagnostic agent with high light-to-heat transformation performance and fluorescence/photoacoustic imaging (FLI/PAI) with the range of near-infrared-II (NIR-II; 900 to 1,700 nm) has emerged as a popular research topic. This study reported a series of Aza-boron-dipyrromethenes (Aza-BODIPY) dyes (Aza-A/B/C) with donor-acceptor structure through the introduction of diethylaminobenzene (electron donor) and (iso)quinoline (electron acceptor) into the Aza-BODIPY backbone. Compared to Aza-A/B, the enhanced light trapping ability, the decreased

SUBMITTER: Wang K 

PROVIDER: S-EPMC12688475 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature