Comparison of metagenomic next-generation sequencing (mNGS) technology with routine laboratory culture for bacterial and fungal detection in bronchoalveolar lavage fluid.

ABSTRACT:

Background

Pulmonary infections continue to threaten human health. Metagenomic next-generation sequencing (mNGS) technology provides a rapid detection method for identifying the pathogens responsible for pulmonary infections, with many advantages compared to traditional culture method. Our objective is to collect and analyze testing data from patients with pulmonary infections at the Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, in order to compare the detection rates of mNGS and traditional culture method.

Methods

This study conducted a retrospective analysis of bronchoalveolar lavage fluid (BALF) samples from 50 patients with pulmonary infections at the Department of respiratory medicine, Union Ho

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12688481 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature