The role of targetable biomarker alterations in overall survival for non-small cell lung cancer (NSCLC) in a large integrated health system.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) comprises 85% of lung cancer cases and remains a leading cause of cancer-related mortality. Advances in next-generation sequencing (NGS) have enabled identification of actionable oncogenic alterations, though real-world data on the prognostic impact of these alterations in NSCLC are limited. This study aims to evaluate the association between specific oncogenic biomarker alterations and overall survival (OS) across all stages of NSCLC in a large, integrated health system, providing real-world evidence on the prognostic value of molecular profiling beyond treatment effects.

Methods

This retrospective cohort study included patients aged 18-89 years with primary NSCLC of all stages diagnosed between 2013 and 2020 from a large integr

SUBMITTER: Jarrin Lopez A 

PROVIDER: S-EPMC12688483 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature