Diagnostic value of pleural fluid carbohydrate antigen 242 for malignant pleural effusion.

ABSTRACT:

Background

Carbohydrate antigen 242 (CA242) shows potential as a tumor marker in the diagnosis of malignant pleural effusion (MPE). However, previous studies have been limited by small sample sizes and a narrow range of etiological types. Therefore, this study aims to reevaluate the diagnostic value of CA242 for MPE by expanding the sample size, encompassing diverse etiologies, and employing electrochemiluminescence immunoassay combined with receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA).

Methods

We prospectively recruited patients with undiagnosed pleural effusions from Hohhot, China, and measured pleural fluid CA242 concentrations using electrochemiluminescence. The diagnostic accuracy and net clinical benefit of pleural fluid CA24

SUBMITTER: Lin X 

PROVIDER: S-EPMC12688494 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature