Resveratrol restores glucocorticoid receptor and HDAC2 to overcome corticosteroid resistance in cigarette smoke-induced emphysema mice.

ABSTRACT:

Background

The primary challenge in treating chronic obstructive pulmonary disease (COPD) with anti-inflammatory medications is corticosteroid resistance. Resveratrol (RSV), a natural polyphenolic compound, has garnered significant interest due to its potent antioxidant and anti-inflammatory effects. This research sought to explore the potential impact of RSV on corticosteroid re-sensitization in emphysema mice triggered by cigarette smoke (CS) exposure.

Methods

Western blotting was employed to assess glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) levels in lung tissues from individuals with COPD. Lung histomorphology was evaluated in mice with CS exposure and a combination of RSV and budesonide (BUD) treatment. Expression levels of GR and HDAC2 were determin

SUBMITTER: Huo Z 

PROVIDER: S-EPMC12688503 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature