Effects of driving pressure-guided lung-protective ventilation strategy on respiratory mechanics, oxygenation, and postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy: a randomized clinical trial.

ABSTRACT:

Background

Minimally invasive Ivor Lewis esophagectomy (MIE) is a primary treatment option for esophageal cancer. However, intraoperative pneumoperitoneum and one-lung ventilation (OLV) significantly alter respiratory mechanics, potentially leading to hypoxemia and postoperative pulmonary complications (PPCs). The objective of this study was to evaluate the effects of a driving pressure (DP)-guided lung-protective ventilation strategy on respiratory mechanics, oxygenation levels, and the occurrence of PPCs in patients undergoing MIE.

Methods

This study was a single-center, prospective, randomized controlled clinical trial. Sixty patients undergoing MIE were randomly assigned to either a conventional lung-protective ventilation strategy group (VC group) or a DP-guided lung-pr

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12688511 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature