SCM-198 ameliorates pulmonary arterial hypertension by modulating gut microbiota in rats.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disorder characterized by pulmonary vascular remodeling and inflammation. This study aimed to investigate the therapeutic effects of SCM-198 (Leonurine) on monocrotaline (MCT)-induced PAH and its role in modulating gut microbiota composition and vascular signaling pathways.

Methods

A rat model of PAH was established via one-time intraperitoneal injection of MCT (50 mg/kg), followed by SCM-198 treatment (50 and 100 mg/kg) for 3 weeks. Pulmonary vascular remodeling was assessed by histological and morphometric analyses. 16S rRNA sequencing was performed to evaluate gut microbiota diversity and composition. Network pharmacology analysis was conducted to identify SCM-198 targets, including o

SUBMITTER: Xiong J 

PROVIDER: S-EPMC12688580 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature