Phylogenetic Analysis, Morphological Characteristics, and Cellular Tropism of Vaccine-Like Recombinant Strains of Lumpy Skin Disease Virus in China.

ABSTRACT: Lumpy skin disease virus (LSDV) causes lumpy skin disease (LSD), a highly contagious cattle disease that leads to substantial economic losses to the global cattle industry. Currently, it is imperative to further elucidate its biological characteristics and analyze the global epidemiological dynamics. In this study, two isolates of LSDV with genetic recombination were identified in Northern and Eastern China, which demonstrated broad host cell entry ability. Through electron microscopy, we further revealed its morphogenetic characteristics across its replication cycle for the first time. Viral particles sequentially formed crescent membranes, nucleoids, and lateral bodies, and ultimately developed into four types of mature virions: intracellular mature virions (IMVs), intracellular envelope

SUBMITTER: Gong Z 

PROVIDER: S-EPMC12688635 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature