MRI-derived extracellular volume fraction as a prognostic biomarker for early recurrence after R0 resection of pancreatic ductal adenocarcinoma.

ABSTRACT:

Objectives

Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence risk after R0 resection. This study aimed to evaluate the prognostic value of preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters, including volume transfer constant (K^trans), rate constant (k_ep), extracellular extravascular volume fraction (v_e), and MRI-derived extracellular volume (ECV) fraction, for predicting early recurrence and survival after surgery.

Methods

In this retrospective cohort study, 61 patients (mean age 60.7 ± 9.7 years; 35 males) with histologically confirmed PDAC underwent preoperative 3 T MRI between January 2017 and May 2024, including DCE-MRI and dual-time-point T1 mapping. Two radiologists indepe

SUBMITTER: Liu JY 

PROVIDER: S-EPMC12688666 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature