Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke.

ABSTRACT: Natural products (NPs) are an important source of new drugs for the treatment of stroke. Identifying cellular targets for bioactive molecules is a major challenge and critical issue in the development of new drugs for stroke. Small-molecule probes play a unique role in target discovery. However, drawbacks to these probes include non-specificity, unstable activity, and difficulty in synthesis. Small-molecule probes based on NPs at least partially compensate for these shortcomings. NPs feature rich chemical and structural diversity, biocompatibility, and unique biological activities. These features could be exploited to provide new ideas and tools for target discovery. Small-molecule probes based on NPs provide a precise and direct search for interacting protein targets of NPs-active small m

SUBMITTER: Jin X 

PROVIDER: S-EPMC12688682 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature