Immunogenicity of second booster-dose COVID-19 mRNA vaccine among older adults in Taiwan.

ABSTRACT:

Background

Limited research has explored the immunological effects of a second COVID-19 vaccine booster in older adults within Western Pacific countries.

Methods

This study involved healthcare workers aged ≥65 years who received two doses of ChAdOx1 nCoV-19 (A), mRNA-1273 (M), or MVC-COV1901 (Mc), followed by a booster dose of mRNA-1273. Younger adults served as controls. Humoral and cellular immune responses were measured before and after the vaccination.

Results

Younger adults exhibited the highest fold-rise in anti-spike IgG levels (13.20, p < 0.001), followed by the AAMM (9.93, p < 0.001), McMcMM (6.97), and MMMM (4.9, p < 0.05) groups. Cellular response increased most in the McMcMM group (3.77), followed by AAMM (3.04, p < 0.001), MMMM (2.24), and the younger gro

SUBMITTER: Lee HY 

PROVIDER: S-EPMC12688691 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature