Cathepsins effect on diffuse large B cell lymphoma risk: A Mendelian randomization study.

ABSTRACT: Recently, the relationship between cathepsins and a variety of diseases has gained increasing attention, especially various solid tumors and hematologic malignancies. However, there is no consensus on the causality between cathepsins and malignant lymphomas. The cathepsin genome-wide association studies (GWAS) dataset for this study was derived from THE INTERVAL STUDY and was freely downloaded via the OPENGWAS website. GWAS summary statistics for lymphomas were obtained from the FinnGen database. Single nucleotide polymorphisms satisfying the genome-wide association significance (P < 5 × 10-6) and linkage disequilibrium parameters (r2 = 0.001 and clumping distance = 10,000 kb) were screened for the subsequent 2-sample Mendelian randomization (MR) analysis. Sensitivity analyses were utilize

SUBMITTER: Lu C 

PROVIDER: S-EPMC12688782 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature