Plasma proteins and osteosarcoma: Mendelian randomization analysis and targeted therapeutic discovery.

ABSTRACT: Prior research has hinted at a possible link between plasma protein metabolites and osteosarcoma (OS). However, no conclusive evidence has been presented to firmly establish a direct connection between particular plasma proteins and OS. To fill this research void, our study utilizes Mendelian randomization (MR) analysis to meticulously assess the causal impact of plasma proteins on the development of OS. Additionally, we aim to discover new plasma protein biomarkers that could serve as potential targets for therapeutic strategies in the treatment of OS. In this study, we leveraged the plasma protein quantitative trait locis data from Ferkingstad et al genome-wide analysis as the exposure variables. Meanwhile, the summary statistics of OS were sourced from the FinnGen database. We construct

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12688887 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature