Identification of key biomarkers and immune infiltration in the co-occurrence of oral lichen planus and Hashimoto's thyroiditis by integrated bioinformatics analysis.

ABSTRACT: Increasing evidence have suggested the co-occurrence of oral lichen planus (OLP) and Hashimoto thyroiditis (HT), the underlying mechanism remains unclear. The aim of our study was to investigate co-expressed differentially expressed genes (co-DEGs) of OLP and HT, elucidate the mechanisms responsible for co-occurrence of OLP and HT. The expression profiles of GSE52130 and GSE29315 were downloaded from the Gene Expression Omnibus database to obtain DEGs between disease group and healthy control group by GEO2R. Enrichment analysis of co-DEGs were performed by Metascape platform. The protein-protein interaction (PPI) network of co-DEGs were developed utilizing the STRING database. Subsequently, CIBERSORT was utilized to evaluate the infiltration of immune cells in OLP and HT. Finally, enzyme-l

SUBMITTER: Feng H 

PROVIDER: S-EPMC12688925 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature