Causal association of education attainment with aging and cardiac death: Evidence from Mendelian randomization analysis.

ABSTRACT: It is challenging to conduct randomized controlled trials of educational attainment (EA) on aging and cardiac death due to the time, cost and ethical constraints involved. However, it has been suggested that EA may influence the onset of aging and cardiac death. Therefore, we used Mendelian randomization (MR) analysis to explore the relationship of EA with aging and cardiac death. The summary-level data for exposure and outcome of individuals with European ancestry were obtained from publicly available genome-wide association studies. The principal analysis employed the random inverse-variance weighted (IVW) method. The MR-Egger intercept test was conducted to evaluate the possibility of pleiotropic effect. The heterogeneity of the selected single nucleotide polymorphisms was evaluated by

SUBMITTER: Fan G 

PROVIDER: S-EPMC12689138 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature