A case report of mixed-phenotype acute leukemia with atypical BCR::ABL1 e13a3 fusion gene.

ABSTRACT:

Rationale

Mixed-phenotype acute leukemia (MPAL) is a type of acute leukemia which is characterized by immunophenotypic features of myeloid, T-lymphoid, and/or B-lymphoid differentiation. The Philadelphia chromosome-positive (Ph+) MPAL, a rare subtype of MPAL, represents <1% of adult acute leukemia cases and typically has a poor prognosis. Here we report a very unique case of MPAL with Ph + atypical e13a3 breakpoint cluster region (BCR)::ABL1 fusion protein and provide new perspectives on the diagnosis and management of Ph + MPAL.

Patient concerns

We present a 64-year-old male who experienced high-grade fever, nasal congestion, and a runny nose 20 days after contracting a cold. A chest computed tomography revealed double pneumonia. The patient was presented with an anemic app

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12689148 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature