Characteristics of Study Design and Statistical Analysis in OCT-Based Studies of Neurodegeneration.

ABSTRACT:

Purpose

To evaluate the design and statistical analysis of recently published clinical studies of retina OCT of neurodegenerative diseases.

Design

Review of 134 publications.

Methods

Clinical and translational publications from 2013-2023 involving human OCT studies were reviewed. Publications were restricted to the top 10 journals of either ophthalmology or neurology based on the SCImago Journal Rank. Data were extracted and analyzed regarding study design characteristics, disease studied, imaging characteristics, and statistical analysis method.

Main outcome measures

Characteristics of study design and statistical analysis.

Results

Of the 134 studies, the most commonly investigated diseases were multiple sclerosis (47.8%), Alzheimer disease (31.3%), and

SUBMITTER: Caplash S 

PROVIDER: S-EPMC12689194 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature