Laboratory Prognostic Index (LAB-PI) in diffuse large B-cell lymphoma: a single blood analysis predicts outcomes as good as IPI, NCCN-IPI, and GELTAMO-IPI.

ABSTRACT:

Background

Many prognostic variables have been described in diffuse large B-cell lymphoma (DLBCL) and combined in prognostic scores, which are not usually fully objective and may be complex to apply. With the aim of designing and validating a simple, inexpensive, objective, and reproducible prognostic tool in DLBCL, the Laboratory Prognostic Index (LAB-PI) was developed.

Patients and methods

Laboratory parameters routinely evaluated at DLBCL diagnosis were analysed before treatment initiation in a DLBCL cohort (n = 221). The variables associated with event-free survival (EFS) were combined into the new score and graded according to their prognostic impact in multivariate analysis. Patients were clustered according to their risk. The LAB-PI was validated in an independent coh

SUBMITTER: Martin-Moro F 

PROVIDER: S-EPMC12689209 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature