Engineering a targeted daphnetin delivery system to enhance spinal cord injury treatment effectiveness.

ABSTRACT: Spinal cord injury (SCI) is a severe central nervous system disorder characterized by complex neuroinflammatory responses. While natural compounds such as daphnetin have demonstrated anti-inflammatory and neuroprotective effects, their clinical application is hindered by low bioavailability. To address this limitation, we developed a biofabricated nanoliposomal drug delivery system, designed to enhance daphnetin's targeted delivery to macrophages and improve its therapeutic efficacy in SCI repair. A biofabrication-driven approach was employed to synthesize and optimize targeted liposomal nanocarriers (Da@Lip-CRV) using phospholipid-based vesicles conjugated with CRVLRSGSC peptides for macrophage specificity. Their targeting and therapeutic efficiency were evaluated in vitro and in vivo. Th

SUBMITTER: Shang J 

PROVIDER: S-EPMC12689221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature