Amyloid-negative neuropsychological norms: Added value in the era of biomarkers and disease-modifying therapies.

ABSTRACT:

Introduction

We previously applied generalized additive models for location, scale, and shape to derive amyloid β-negative next-generation norms (NGN) for a comprehensive neuropsychological battery. Here, we evaluated the accuracy of NGN in detecting cognitive impairment compared to traditional norms (TN).

Methods

This multicenter study included N = 2405 participants classified as cognitively normal (CN, n = 987) or with mild cognitive impairment (MCI, n = 1418) using conventional criteria. All participants underwent neuropsychological testing and cerebrospinal fluid Alzheimer's disease (AD) biomarker assessment. We used actuarial neuropsychological criteria to reclassify all participants using TN and NGN. Diagnostic groups were compared on cognitive per

SUBMITTER: Rubio-Guerra S 

PROVIDER: S-EPMC12689264 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature