Broadening Virus Resistance Through Gene Pyramiding of eIF4E Family Members.

ABSTRACT: Recessive resistance, achieved through mutations in host susceptibility genes, offers an effective way for controlling plant viruses. One well-studied gene family involved in such resistance is the eukaryotic translation initiation factor 4E (eIF4E) gene family, which includes eIF4E, eIFiso4E and the atypical novel cap-binding protein (nCBP). Although gene pyramiding of the eIF4E family may provide a promising strategy for broadening virus resistance, it has so far been applied only to a limited set of gene combinations and target viruses. To deepen our understanding of the practicality of eIF4E family gene pyramiding, we analysed a comprehensive set of eIF4E family knockout mutants and six phylogenetically diverse viruses. Double-gene mutant lines ncbp eif4e1 and ncbp eifiso4e exhibited r

SUBMITTER: Suzuki M 

PROVIDER: S-EPMC12689272 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature