Exploring therapeutic mechanism of Fuzhenghefuzhiyang Formula in psoriasis: inflammation and metabolism regulation.

ABSTRACT:

Background

Psoriasis is a long-term, immune-mediated inflammatory disorder of the skin, affecting about 2-3% of the global population with rising prevalence rates. Clinical practice has demonstrated that Fuzhenghefuzhiyang formula (FZHFZY), a topical medication applied Chinese herbal formula developed by Prof. Lu Chuanjian, exhibits significant efficacy in alleviating psoriasis symptoms. Nevertheless, its mechanism of anti-psoriasis remains unclear.

Purpose

The purpose of this study is to decode the molecular mechanisms by which FZHFZY produces its therapeutic effects on psoriasis using an integrated multi-omics approach.

Methods

Employing both cell-based and animal studies, we systematically elucidate the pharmacodynamic substance basis and biological pathways underl

SUBMITTER: Tang B 

PROVIDER: S-EPMC12689303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature