A novel TNFR2 agonist peptide for the expansion of CD4+Foxp3+ regulatory T cells.

ABSTRACT: CD4⁺Foxp3⁺ regulatory T cells (Tregs) are essential for maintaining immune tolerance, and selective expansion of Tregs via TNFR2 signaling represents a promising therapeutic approach for autoimmune and inflammatory diseases. Here, we report the identification and characterization of UMR2-705, a novel TNFR2 agonist discovered through phage display screening. In vitro, peptide UMR2-705 selectively promoted Treg proliferation in both human peripheral blood mononuclear cells and murine CD4⁺ T cell cultures without stimulating conventional CD4⁺ effector or CD8⁺ T cells. This effect was abrogated by the TNFR2-specific blocking antibody TR75-54.7, indicating its TNFR2 dependency. In vivo, administration of peptide UMR2-705 expan

SUBMITTER: Liao P 

PROVIDER: S-EPMC12689330 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature