Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis.

ABSTRACT:

Objective

Although obesity is widely reported as an established risk factor for gastroesophageal reflux disease (GERD), divergent findings exist across studies. To address the problems of obsolete data and conflicting findings in previous studies, we conducted a systematic review and meta-analysis to explore the association between body mass index (BMI) and GERD.

Methods

We searched Pubmed, Embase, Cochrane Library, and Web of Science for relevant studies, and obtained the prevalence of symptomatic gastroesophageal reflux (symptomatic GER) or GERD from the original studies for the different BMI groups. International BMI cut-off points were adopted to define underweight, overweight, and obesity. Meta-analysis of this association was performed by calculating the combined relat

SUBMITTER: Yiqing M 

PROVIDER: S-EPMC12689342 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature