The GPCR A35 regulates fecundity of <i>Nilaparvata lugens</i> Stal via juvenile hormone signaling.

ABSTRACT: The brown planthopper, Nilaparvata lugens is a major rice pest in Asia, with its high fecundity contributing to recurrent outbreaks. G protein-coupled receptors (GPCRs) are a critical class of transmembrane proteins in insects that sense diverse extracellular and intracellular signals and regulate a wide range of physiological processes. In this study, we characterized GPCR A35 and its function in N. lugens fecundity. Expression profiling revealed that GPCR A35 was highly enriched in female heads and fat bodies, with peak levels in females at 4 days post-eclosion. RNAi-mediated the silencing of GPCR A35 in fifth-instar nymphs by 57-60%, and was effectively delivered to female adults, resulting in a 14.8% reduction in juvenile hormone (JH) titer and marked downregulatio

SUBMITTER: Cao M 

PROVIDER: S-EPMC12689387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature