Case Report: Two cases of non-small cell lung cancer with coexistence of <i>NTRK2</i> fusion and <i>EGFR</i> mutations.

ABSTRACT:

Objective

To investigate the clinical and pathological characteristics of patients with non-small cell lung cancer exhibiting coexistence of NTRK2 fusion and EGFR mutations.

Methods

Clinical data, as well as histopathological, immunohistochemical, and molecular pathological characteristics, of two patients harboring both NTRK2 gene fusions and EGFR gene mutations were retrospectively analyzed, and relevant literature was also reviewed.

Results

Both patients were women aged 57 and 66 years. The two cases were diagnosed as invasive lung adenocarcinoma, and immunohistochemical staining showed that all tumor cells expressed CK7, Napsin A, TTF-1, and PD-L1. In Case 1, an EGFR mutation in the primary lung lesion, coexistence of NTRK2

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12689392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature