Computationally-directed mechanical ventilation in a porcine model of ARDS.

ABSTRACT:

Background

Despite the implementation of protective mechanical ventilation, ventilator-induced lung injury remains a significant driver of ARDS-associated morbidity and mortality. Mechanical ventilation must be personalized and adaptive for the patient and evolving disease course to achieve sustained improvements in patient outcomes. In this study, we modified a military-grade transport ventilator to deliver the airway pressure release ventilation (APRV) modality. We developed a computationally-directed (CD) method of adjusting the expiratory duration (T_Low) during APRV using physiologic feedback to reduce alveolar derecruitment and tested this modality in a porcine model of moderate-to-severe ARDS.

Methods

Female Yorkshire-cross pigs (n = 27) were ventilated usin

SUBMITTER: Kollisch-Singule M 

PROVIDER: S-EPMC12689400 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature