Low-dose statins combined with repetitive transcranial magnetic stimulation reduce post-stroke depression.

ABSTRACT:

Background

The effectiveness of statins in preventing post-stroke depression (PSD) remains controversial. Lower testosterone levels caused by statins could potentially increase the risk of PSD. Low-dose statins could offer better benefits due to their lesser impact on testosterone levels. Repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce PSD in the acute stage. The combination of low-dose statins and rTMS may provide a promising therapeutic option for patients with PSD.

Methods

Data were collected from ischemic stroke patients. Unsupervised machine learning methods were employed to explore the risk factor of PSD. Our prospective cohort study collected data from ischemic stroke patients over 3 years. The patients' conditions determined the prescript

SUBMITTER: Cui C 

PROVIDER: S-EPMC12689410 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature