The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review.

ABSTRACT:

Background

High fructose corn syrup (HFCS) is a dietary sweetener that is used in a substantial portion of food and beverages. Recent evidence has cited dietary HFCS as a risk factor in the development of obesity, metabolic syndrome, and liver disease. This systematic review provides a new evaluation of the potential hepatic and metabolic risks posed by HFCS to inform both clinical practice and public health policy.

Methods

We conducted a systematic review of English-language, human studies of adults (≥18 years) with low to no alcohol intake using Covidence. Only quantitative studies that specified a link supported by direct evidence between HFCS and markers of liver injury or glucose metabolism in the setting of MASLD or NAFLD were included.

Results

The literature se

SUBMITTER: Yu ZZ 

PROVIDER: S-EPMC12689413 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature