White matter hyperintensity modulates the amyloid-tau-cognition association and anti-amyloid treatment efficacy in asymptomatic older adults.

ABSTRACT:

Introduction

White matter hyperintensities (WMH), a key imaging biomarker of small vessel injury, may play a complex role in Alzheimer's disease (AD). We hypothesize that WMH not only directly contributes to cognitive decline but also moderates the relationship among AD pathology, treatment, and cognitive decline.

Methods

A total of 1169 participants with 240-week follow-up in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study were analyzed. Linear regression models examined WMH's contribution to cognitive decline, its interaction with Aβ on p-Tau217 level, and its interaction with anti-amyloid treatment on cognitive decline.

Results

Increase in WMH volume independently contributed to cognitive decline (p = 0.0028). Baseline WMH significantly moderated

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12689459 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature