Understanding the Association of Plasmid Incompatibility Groups With Variable Antimicrobial Resistance Genotypes in Bacteria.

ABSTRACT: Plasmids play an essential role in the spread of antimicrobial resistance (AMR) by facilitating the horizontal transfer of resistance genes between bacterial environments. However, large-scale investigations into the association between plasmid incompatibility groups (Inc groups) and specific resistance profiles remain limited. In this study, we analyzed 28,047 plasmid sequences from publicly available whole-genome sequencing data sets, identifying incompatibility groups in 11,288 plasmids using in silico replicon typing. Our results revealed that the majority of plasmids harbored a single replicon, while a substantial fraction carried multiple replicons, predominantly two. We evaluated the relationship between plasmid replicon spillovers and their role in the spread of resistance genes. O

SUBMITTER: de Souza HCA 

PROVIDER: S-EPMC12689464 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature