Efficacy and Safety of Laser Treatment in Vulvar Lichen Sclerosus: A Systematic Review.

ABSTRACT:

Objectives

This study systematically reviews randomized controlled trials (RCTs) evaluating laser therapy for vulvar lichen sclerosus (VLS) to assess its efficacy and safety, aiming to inform clinical management and guideline development.

Methods

RCTs on laser treatment for VLS were retrieved from PubMed, Embase, Web of Science, and Cochrane databases up to January 2025, limited to English literature. References from included studies were also screened. Data on study characteristics, laser parameters, outcome measures, measurement tools, and assessment time points were extracted and analyzed.

Results

Seven RCTs (332 patients) reported 19 outcomes and 19 measurement tools, each used a total of 28 times. Symptoms and signs were most frequently reported and commonly meas

SUBMITTER: Wei D 

PROVIDER: S-EPMC12689481 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature