Toxicity evaluation of laser-synthesized pro-angiogenic carbon monoxide-rich gold nanoparticles <i>in vitro</i> and <i>in vivo</i>.

ABSTRACT:

Introduction

The safety profile of gold nanoparticles remains a concern and depends on dose, size, surface chemistry and charge. This study evaluated through in vitro and in vivo methods the cytotoxicity, oxidative stress and genotoxicity of laser synthesized carbon monoxide-Rich Gold Nanoparticles (COR-AuNPs), which can strongly promote angiogenesis in endothelial colony forming cells (ECFC).

Methods

COR-AuNPs were synthesized by pulsed laser driven CO₂ reduction reaction, and stabilized for culture media with the addition of the copolymer Pluronic-F127 (PF127). The fresh synthetized nanoparticles where characterized for size and morphology. Their stability was investigated in both culture media and the water aquarium environment. In vitro Cy

SUBMITTER: Gomes Araujo TB 

PROVIDER: S-EPMC12689510 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature