Combined effects of insulin resistance and altitude of residence on 10-year risk of atherosclerotic cardiovascular disease.

ABSTRACT:

Background

The combined health effects of the triglyceride-glucose (TyG) index and altitude of residence on the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) remain unknown. We examined the combined effect of the TyG index and altitude of residence on ASCVD using data from two cross-sectional studies.

Methods

We included 6,861 participants with no history of ASCVD from two cross-sectional studies and assessed their 10-year risk of ASCVD using the China-PAR model. We stratified the TyG index and altitude of residence and used multivariate-adjusted logistic models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for a high 10-year risk of ASCVD. Both additive and multiplicative effects were considered.

Results

A total of 6,861 participan

SUBMITTER: Xia Y 

PROVIDER: S-EPMC12689511 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature