Comparative metagenomic analysis on COPD and health control samples reveals taxonomic and functional motifs.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a progressive lung condition marked by persistent respiratory symptoms and airflow limitation and significantly affects global health. The intricate relationship between COPD and the lung microbiome has garnered attention, with metagenomic analyses revealing critical insights into microbial community dynamics and their functional roles. In this study, we conducted a comprehensive metagenomic analysis comparing throat samples from COPD patients (n = 26) and healthy controls (n = 32) derived from a large cohort analyzed at the Saarland University Hospital. Taxonomic profiling and differential abundance analysis indicated a significant reduction of the microbial diversity in COPD patients, with notable overrepresentation of pathoge

SUBMITTER: Chen G 

PROVIDER: S-EPMC12689518 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature