Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in bladder cancer.

ABSTRACT: To investigate the predictive value of Endothelial cell-specific molecule 1 (ESM1) assay for early diagnosis and treatment of bladder cancer (BC) patients. In this study, 1558 clinical samples were included to explore the differential expression of ESM1 mRNA in BC, and in-house samples (n = 195) were collected for immunohistochemistry experiments to validate at the ESM1 protein level. ChIP-Seq, ATAC-seq, and histone modification data were integrated by Cistrome Data Browser to resolve the epigenetic regulatory mechanisms of ESM1. Single-cell sequencing analysis was used to mine the differential expression and intercellular communication of ESM1 at the cellular level. Further, GSEA and STRING were used to construct a PPI network and combined with Cytospace to mine Hub genes to reveal the im

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12689700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature